Current Trends and Gaps in Gout Management Guidelines: A Critical Review DOI: https://doi.org/10.55522/jhpo.V2I2.0024

Abstract

Gout, the most common inflammatory arthritis worldwide, remains suboptimally managed despite well-established guidelines. This review critically evaluates current international gout management guidelines, identifies persistent gaps in implementation, and explores emerging trends. While guidelines agree on core principles like urate-lowering therapy (ULT) for chronic gout, significant variations exist in treatment targets, drug selection, and management approaches for comorbidities. Key challenges include poor guideline adherence (30-50% in real-world practice), disparities in care access, and insufficient attention to special populations. Emerging solutions include precision medicine approaches, novel therapeutics (e.g., interleukin-1 inhibitors), and digital health strategies. This analysis synthesizes evidence from 12 major guidelines and 120+ studies to provide a roadmap for improving gout care globally.