A review on Psidium Guajava & Jasminum for mouth ulcer Doi: https://doi.org/10.55522/jhpo.V2I6.0058

Abstract

Aphthous ulcers, another name for mouth ulcers, are painful sores that affect the oral cavity's mucous membrane and are frequently brought on by stress, malnutrition, or microbial infections. The ethanolic extract of Psidium guajava (guava) leaves, & Jasmine leaves extract, which are well- known for their strong anti-inflammatory, antibacterial, and wound-healing qualities, will be used in the current study to create and assess a herbal mouth ulcer gel. The guava leaves were pulverized, shade-dried, and extracted using the maceration technique with ethanol. Using peppermint oil as a flavoring and glycerin as a humectant, the extract was added to a carbopol- based gel. Physicochemical characteristics of the produced formulations, including pH, viscosity, spreadability, extrudability, homogeneity, and stability, were assessed. Using the agar well diffusion method, in vitro antibacterial activity was evaluated against Candida albicans and Streptococcus mutans. Excellent spreadability, acceptable pH (6.5–7.0), and high stability were all demonstrated by the optimised formulation. When compared to a commercial formulation, the gel had strong antibacterial action, suggesting that it could be used as a natural remedy for mouth ulcers. According to the study's findings, Psidium guajava leaf extract can be successfully combined to create a herbal mouth ulcer gel that is both stable and effective, with potential therapeutic benefits.